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in humans, following oral administration of zyban, peak plasma concentration c max of bupropion is usually achieved within 3 hours.
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in a population of individuals experienced with drugs of abuse, a single dose of 400 mg bupropion produced mild amphetamine-like activity as compared to placebo on the morphine-benzedrine subscale of the addiction research center inventories arci , and a score intermediate between placebo and amphetamine on the liking scale of the arci.
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nonetheless, evidence from single-dose studies does suggest that the recommended daily dosage of bupropion when administered in divided doses is not likely to be significantly reinforcing to amphetamine or cns stimulant abusers.
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in a clinical study of 15 male subjects ages 19 to 35 years who were extensive metabolizers of cyp2d6, bupropion given as 150 mg twice daily followed by a single dose of 50 mg desipramine increased the cmax, auc, and t of desipramine by an average of approximately 2-, 5-, and 2-fold, respectively.
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